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Concomitant cure with a MAO inhibitor, antidepressant or other centrally Energetic medication, especially other anoretics In vitro scientific tests indicated the cytochrome P450 (3A4)-mediated metabolism of sibutramine was inhibited by ketoconazole also to a lesser extent by erythromycin. The disposition of sibutramine metabolites (M1, M2, M5 and

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